Web2.0 techniques, especially AJAX creates a beautiful and rich gui for your website. But that doesn't mean a thing to the blind. They just get more trouble because of it. Lawsuits are filed more and more against companies whose websites aren't accessible to the blind - and they're right in a way.
As lighthouse has code to close images or move to the next image for instance by using your keyboard, I think more attention should be paid to the needs of the blind, especially since the web is used more often to purchase stuff making your life a lot easier, blind or not. The whole idea is to be a platform for everyone, not just some.

Link : Agile Ajax
Link : Cnet news on case against Southwest Airlines
Link : Ajaxian reporting about this